Description

Methyl 1-(Benzenesulfonyl)Azetidine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine ring system. This compound is valued for its role as a critical building block in the synthesis of novel, bioactive molecules, particularly in medicinal chemistry. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries who are developing new therapeutic agents, such as protease inhibitors or other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex azetidine-containing active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new drug candidates.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the synthesis of inhibitors targeting various proteases.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and cGMP manufacturing of novel therapeutics.
• Academic Research: Employed in university and institutional labs for pioneering research in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	Methyl 1-(Benzenesulfonyl)Azetidine-3-Carboxylate
CAS No.	1334499-99-8
Molecular Formula	C11H13NO4S
Molecular Weight	255.29 g/mol
Synonyms	1-(Phenylsulfonyl)azetidine-3-carboxylic acid methyl ester; Methyl 1-(phenylsulfonyl)azetidine-3-carboxylate; 1-Benzenesulfonylazetidine-3-carboxylic Acid Methyl Ester; Azetidine-3-carboxylic acid, 1-(phenylsulfonyl)-, methyl ester; Methyl 1-tosylazetidine-3-carboxylate (common alias); 3-(Methoxycarbonyl)-1-(phenylsulfonyl)azetidine
EINECS	Contact for details

Quality Control

Our Methyl 1-(Benzenesulfonyl)Azetidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your development and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.