Description

tert-Butyl 3,3-Difluoro-4-Phenylpiperidine-1-Carboxylate is a high-value, fluorinated piperidine derivative serving as a critical building block in advanced organic synthesis. This compound matters because its unique structure, featuring both a phenyl group and geminal difluoro substitution, is essential for modulating the physicochemical and metabolic properties of target molecules. Pharmaceutical and agrochemical researchers need it for the development of novel active ingredients, particularly in medicinal chemistry where fluorine incorporation is a key strategy for improving potency and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorinated piperidine core can enhance biological activity and environmental stability.
• Chemical Biology Probe Development: Employed as a scaffold for designing molecular probes to study enzyme function and protein-ligand interactions.
• Material Science Research: Acts as a precursor for specialty monomers or ligands in the synthesis of advanced polymers and functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	tert-Butyl 3,3-Difluoro-4-Phenylpiperidine-1-Carboxylate
CAS No.	1334418-85-7
Molecular Formula	C16H21F2NO2
Molecular Weight	297.34 g/mol
Synonyms	1-Boc-3,3-difluoro-4-phenylpiperidine; tert-Butyl 3,3-difluoro-4-phenyl-1-piperidinecarboxylate; 4-Phenyl-3,3-difluoropiperidine-1-carboxylic acid tert-butyl ester; 3,3-Difluoro-4-phenylpiperidine-1-carboxylic acid tert-butyl ester; N-Boc-3,3-difluoro-4-phenylpiperidine; 1-(tert-Butoxycarbonyl)-3,3-difluoro-4-phenylpiperidine; Boc-3,3-difluoro-4-phenylpiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,3-Difluoro-4-Phenylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.