Description

3,3-Difluoro-4-Phenylpiperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1334417-79-6. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D departments, contract research/manufacturing organizations (CROs/CMOs), and fine chemical suppliers engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in medicinal chemistry programs.
• CNS Drug Discovery: Used in the synthesis of potential therapeutics targeting neurological disorders, leveraging the piperidine scaffold's bioactivity.
• Oncology Research: Serves as a precursor in the creation of novel small-molecule inhibitors and targeted cancer therapies.
• Chemical Biology & Proteomics: Employed as a molecular probe or building block for studying biological pathways and protein interactions.
• Process Chemistry & Scale-Up: Utilized in route scouting, optimization, and pilot-scale production for clinical trial material.
• Custom Synthesis: A starting material for the bespoke manufacturing of complex, fluorinated organic molecules for various research applications.

Basic Information

Product Name	3,3-Difluoro-4-Phenylpiperidine Hydrochloride
CAS No.	1334417-79-6
Molecular Formula	C11H14ClF2N
Molecular Weight	233.68 g/mol
Synonyms	4-Phenyl-3,3-difluoropiperidine hydrochloride; 3,3-Difluoro-4-phenylpiperidine HCl; 3,3-Difluoro-4-phenylpiperidine hydrochloride; 4-Phenyl-3,3-difluoropiperidine HCl; 3,3-Difluoro-4-phenyl-piperidine hydrochloride; Piperidine, 3,3-difluoro-4-phenyl-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-4-Phenylpiperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients' pharmaceutical development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.