Description

tert-Butyl 4,4-Difluoro-3-Oxopiperidine-1-Carboxylate is a high-purity, protected piperidine derivative serving as a critical building block in modern synthetic chemistry. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring fluorinated heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Fluorinated Molecule Synthesis: Utilized to introduce the metabolically stable difluoro motif into lead compounds, enhancing their pharmacokinetic properties such as membrane permeability and metabolic stability.
• Protease Inhibitor Development: Serves as a core scaffold for designing and synthesizing inhibitors of various proteolytic enzymes.
• Agrochemical Research: Used in the discovery and development of new generation pesticides and herbicides that leverage fluorinated chemistry for improved efficacy and environmental profile.
• Chemical Biology & Probe Development: Employed in the creation of chemical probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs supporting client projects from milligram to kilogram scale.

Basic Information

Product Name	tert-Butyl 4,4-Difluoro-3-Oxopiperidine-1-Carboxylate
CAS No.	1334416-41-9
Molecular Formula	C10H15F2NO3
Molecular Weight	235.23 g/mol
Synonyms	1-Boc-4,4-difluoro-3-oxopiperidine; 1-(tert-Butoxycarbonyl)-4,4-difluoropiperidin-3-one; 4,4-Difluoro-3-oxo-1-piperidinecarboxylic acid tert-butyl ester; tert-Butyl 4,4-difluoro-3-oxo-1-piperidinecarboxylate; 1-N-Boc-4,4-difluoro-3-piperidone; 3-Oxo-4,4-difluoropiperidine-1-carboxylic acid tert-butyl ester; Boc-4,4-difluoro-3-oxopiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4,4-Difluoro-3-Oxopiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.