Description

tert-Butyl 4,4-Difluoro-3-(2-Methoxy-2-Oxoethyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with strategic fluorine and ester functional groups. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex, fluorinated target compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug discovery programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms and modify ester groups, optimizing drug candidate properties like potency and pharmacokinetics.
• Process Chemistry Development: Serves as a standardized starting material for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Agrochemical Synthesis: Employed in the research and development of novel fluorinated pesticides and herbicides, where the difluoropiperidine moiety can impart desirable biological activity.
• Custom Synthesis & Contract Manufacturing: A valuable substrate for fine chemical suppliers offering bespoke synthesis services for client-specific molecular targets.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and fluorine chemistry.

Basic Information

Product Name	tert-Butyl 4,4-Difluoro-3-(2-Methoxy-2-Oxoethyl)Piperidine-1-Carboxylate
CAS No.	1334413-62-5
Molecular Formula	C14H23F2NO4
Molecular Weight	307.34 g/mol
Synonyms	1-Boc-4,4-difluoro-3-(2-methoxy-2-oxoethyl)piperidine; tert-Butyl 4,4-difluoro-3-(methoxycarbonylmethyl)piperidine-1-carboxylate; 4,4-Difluoro-3-(2-methoxy-2-oxoethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4,4-difluoro-3-(2-methoxy-2-oxoethyl)piperidine; 1334413-62-5; Boc-4,4-difluoro-3-(methoxycarbonylmethyl)piperidine
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 4,4-Difluoro-3-(2-Methoxy-2-Oxoethyl)Piperidine-1-Carboxylate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.