Description

Ethyl 4-Hydroxytetrahydrofuran-2-Carboxylate is a versatile chiral building block and ester derivative of tetrahydrofuran. This compound matters for its role as a key intermediate in the synthesis of complex pharmaceutical molecules and fine chemicals, offering a functionalized scaffold for further chemical modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing chiral tetrahydrofuran motifs.
• Chiral Building Block: Used in asymmetric synthesis to construct complex molecules with defined stereochemistry for drug discovery and development.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, flavors, fragrances, and advanced materials.
• Agrochemical Research: Acts as an intermediate in the development of novel herbicides, fungicides, and plant growth regulators.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies and the preparation of target compounds.
• Process Chemistry: Investigated for scalable routes in pilot plants and commercial manufacturing processes.

Basic Information

Product Name	Ethyl 4-Hydroxytetrahydrofuran-2-Carboxylate
CAS No.	1333319-61-1
Molecular Formula	C7H12O4
Molecular Weight	160.17 g/mol
Synonyms	Ethyl 4-hydroxyoxolane-2-carboxylate; 4-Hydroxytetrahydrofuran-2-carboxylic Acid Ethyl Ester; Ethyl tetrahydro-4-hydroxy-2-furancarboxylate; 2-Furancarboxylic acid, tetrahydro-4-hydroxy-, ethyl ester; Ethyl 4-hydroxydihydro-2-furoate; (4-Hydroxyoxolan-2-yl)formic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Hydroxytetrahydrofuran-2-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay, chiral purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.