Description

5-Bromo-2-Chloro-3-(Difluoromethyl)Pyridine is a high-value halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which provides a versatile scaffold for introducing multiple halogen and fluorine functionalities into target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in medicinal chemistry for creating drug candidates and in crop protection research.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine core and halogen substituents.
• Material Science Research: Employed in the synthesis of functionalized ligands for catalysis or as a monomer for creating specialized polymers and electronic materials.
• Chemical Biology Probes: Serves as a building block for creating molecular probes and tags used in biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated pyridine motifs.

Basic Information

Product Name	5-Bromo-2-Chloro-3-(Difluoromethyl)Pyridine
CAS No.	1332392-76-3
Molecular Formula	C7H3BrClF2N
Molecular Weight	248.46 g/mol
Synonyms	3-(Difluoromethyl)-5-bromo-2-chloropyridine; 2-Chloro-5-bromo-3-(difluoromethyl)pyridine; 5-Bromo-2-chloro-3-difluoromethylpyridine; Pyridine, 5-bromo-2-chloro-3-(difluoromethyl)-; 1332392-76-3
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloro-3-(Difluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports compliance in cGMP and ISO 9001 environments for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.