Description

4-(7-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-6,8-Dioxo-5,7-Diazaspiro[3.4]Octan-5-Yl)-2-Fluoro-n-Methylbenzamide CAS NO 1332391-92-0 is a high-value, complex heterocyclic compound featuring a spirocyclic core, a trifluoromethylpyridine moiety, and a benzamide group. This sophisticated molecular architecture makes it a critical advanced pharmaceutical intermediate for the research and development of novel therapeutics. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in developing targeted small molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique spirocyclic and fluorine-containing motifs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component (ligand or linker) in the design of bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: The structural features suggest utility as a core scaffold or intermediate for novel kinase inhibitor development.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying specific biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Item	Details
Product Name	4-(7-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-6,8-Dioxo-5,7-Diazaspiro[3.4]Octan-5-Yl)-2-Fluoro-n-Methylbenzamide
CAS No.	1332391-92-0
Molecular Formula	C22H14F4N6O3
Molecular Weight	486.38 g/mol
Synonyms	2-Fluoro-4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-6,8-dioxo-5,7-diazaspiro[3.4]oct-5-yl]-N-methylbenzamide; 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide; 1332391-92-0; Spirocyclic pyridinecarboxamide intermediate; Advanced trifluoromethylpyridine intermediate.
EINECS	Contact for details

Quality Control

Our 4-(7-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-6,8-Dioxo-5,7-Diazaspiro[3.4]Octan-5-Yl)-2-Fluoro-n-Methylbenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity analysis, NMR and MS confirmation, and residual solvent screening, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.