Description

7-Boc-3-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane is a high-value, protected heterocyclic building block essential for modern pharmaceutical synthesis. This compound matters because it provides a versatile chiral scaffold with orthogonal protecting groups, enabling the efficient construction of complex molecular architectures. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the research and development of new active pharmaceutical ingredients (APIs), particularly in areas like central nervous system (CNS) and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those containing spirocyclic and bridged heterocyclic motifs.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore new bioactive chemical space.
• Process Chemistry Development: Serves as a critical starting material or advanced intermediate for scaling up the production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Protease Inhibitor Synthesis: Potential building block for the development of inhibitors targeting various protease enzymes.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Asymmetric Synthesis: Exploits its inherent chirality for the stereoselective construction of complex natural products and analogs.

Basic Information

Product Name	7-Boc-3-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane
CAS No.	1331825-50-3
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	tert-Butyl 3-hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate; 7-(tert-Butoxycarbonyl)-3-hydroxy-1-oxa-7-azaspiro[4.4]nonane; 3-Hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylic acid tert-butyl ester; 1-Oxa-7-azaspiro[4.4]nonane-7-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester; Boc-Protected 3-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane; 1331825-50-3
EINECS	Contact for details

Quality Control

Our 7-Boc-3-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive analytical data, including chiral purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.