Description

1-Oxaspiro[4.4]Nonan-3-Ol is a specialized spirocyclic ether alcohol, a high-value intermediate in advanced organic synthesis. This compound matters for its unique bridged-ring structure, which provides a rigid, three-dimensional scaffold critical for developing novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to build molecular complexity and modulate physicochemical properties.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides where the spirocyclic core enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers with unique thermal or mechanical properties.
• Flavor & Fragrance Chemistry: Potential intermediate for creating novel musk-like or complex earthy odorants due to its constrained cyclic structure.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, including ring-opening and functionalization reactions.

Basic Information

Product Name	1-Oxaspiro[4.4]Nonan-3-Ol
CAS No.	1331825-49-0
Molecular Formula	C8H14O2
Molecular Weight	142.20 g/mol
Synonyms	1-Oxaspiro[4.4]nonan-3-ol; 3-Hydroxy-1-oxaspiro[4.4]nonane; Spiro[4.4]nonane-3-ol, 1-oxa-; Oxaspiro[4.4]nonan-3-ol; 1-Oxa-spiro[4.4]nonan-3-ol; 3-Hydroxyoxaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our 1-Oxaspiro[4.4]Nonan-3-Ol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support development projects requiring compliance with ICH guidelines and can supply material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.