Description

7-Chloro-8-Iodo-2-(Trifluoromethyl)Imidazo-[1,2-A]Pyridine is a high-value, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring chlorine, iodine, and trifluoromethyl substituents on the imidazopyridine core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, where its halogen atoms serve as versatile handles for further functionalization via cross-coupling and nucleophilic substitution reactions.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used as a building block for synthesizing novel herbicides, fungicides, and insecticides, leveraging the bioactivity often associated with halogenated heterocycles.
• Material Science Precursor: Serves as a specialized monomer or ligand precursor in the development of advanced organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Biology Probe: Employed in the synthesis of molecular probes and tags for studying biological processes, where the iodine atom allows for radiolabeling or further bioconjugation.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig) to create diverse chemical libraries.
• Fluorine Chemistry Building Block: The presence of the trifluoromethyl group provides a source of fluorine, which is valuable for modulating lipophilicity, metabolic stability, and bioavailability in lead optimization.

Basic Information

Product Name	7-Chloro-8-Iodo-2-(Trifluoromethyl)Imidazo-[1,2-A]Pyridine
CAS No.	1331823-98-3
Molecular Formula	C9H3ClF3IN2
Molecular Weight	361.48 g/mol
Synonyms	7-Chloro-8-iodo-2-(trifluoromethyl)imidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 7-chloro-8-iodo-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-7-chloro-8-iodoimidazo[1,2-a]pyridine; 7-Chloro-8-iodo-2-trifluoromethylimidazo[1,2-a]pyridine; 1331823-98-3; Halogenated Imidazopyridine Building Block
EINECS	Contact for details

Quality Control

Every batch of 7-Chloro-8-Iodo-2-(Trifluoromethyl)Imidazo-[1,2-A]Pyridine is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development applications. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent levels are supplied with each shipment. Our quality commitment supports compliance with the standards required for pharmaceutical intermediate use under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage to maintain stability and purity. Recommended storage temperature is 2-8°C for extended periods.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.