Description

1-Piperidinecarboxylic Acid, 4-Amino-3-Hydroxy-, 1,1-Dimethylethyl Ester, (3R,4S)-Rel- is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of protease inhibitors, neurological agents, and other complex drug candidates.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where specific stereochemistry influences biological activity.
• Peptidomimetics & Bioactive Molecules: Serves as a constrained amino acid analog for designing peptide-like molecules with enhanced stability and potency.
• Catalyst & Ligand Development: Employed as a precursor for creating novel chiral catalysts and ligands used in asymmetric synthesis.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.
• Fine Chemical Synthesis: Integral to multi-step synthetic routes for producing high-value, optically active specialty chemicals.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-Amino-3-Hydroxy-, 1,1-Dimethylethyl Ester, (3R,4S)-Rel-
CAS No.	1331777-74-2
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	rel-(3R,4S)-4-Amino-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl (3R,4S)-4-amino-3-hydroxypiperidine-1-carboxylate; (3R,4S)-4-Amino-3-hydroxy-1-Boc-piperidine; 1-Boc-4-amino-3-hydroxypiperidine (rel-(3R,4S)-); 4-Amino-3-hydroxy-1-N-Boc-piperidine; 1-N-Boc-4-amino-3-hydroxypiperidine; Boc-4-Amino-3-hydroxypiperidine; Amino-hydroxy piperidine Boc derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets high-purity specifications suitable for research and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available upon request. Our quality system is designed to support the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.