Description

(E/Z)-N,n-Didesmethyl-4-Hydroxy Tamoxifen 2'-Azide is a key synthetic intermediate and derivative of the selective estrogen receptor modulator (SERM) tamoxifen, modified with an azide functional group. This compound is of significant value for pharmaceutical research and development, particularly in the synthesis of novel drug conjugates and probes for targeted therapies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors engaged in anticancer drug discovery, chemical biology, and proteomics studies.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of next-generation tamoxifen analogs and targeted cancer therapeutics.
• Chemical Biology Probe Development: The azide group enables bioorthogonal click chemistry (e.g., CuAAC, SPAAC) for labeling, pull-down assays, and target identification studies.
• Proteomics Research: Used to create affinity probes for studying estrogen receptor (ER) interactions and signaling pathways in breast cancer research.
• ADC (Antibody-Drug Conjugate) Payload Synthesis: Serves as a precursor for constructing potent cytotoxins linked to targeting antibodies.
• Metabolite & Biomarker Analysis: Reference standard for the analytical study of tamoxifen metabolites in pharmacokinetic and pharmacodynamic research.
• Medicinal Chemistry: Core scaffold for structure-activity relationship (SAR) studies to develop new SERMs with improved efficacy and reduced side effects.

Basic Information

Item	Details
Product Name	(E/Z)-N,n-Didesmethyl-4-Hydroxy Tamoxifen 2'-Azide
CAS No.	1331643-32-3
Molecular Formula	C24H25N3O2
Molecular Weight	387.48 g/mol
Synonyms	4-Hydroxy-N-desmethyltamoxifen azide; 2'-Azido-4-hydroxy-N-desmethyltamoxifen; (Z)-4-(1-(4-(2-Azidoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol; (E)-4-(1-(4-(2-Azidoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol; Tamoxifen metabolite azide derivative; Endoxifen azide analog; N,N-Didesmethyl-4-hydroxy Tamoxifen 2'-Azide
EINECS	Contact for details

Quality Control

Our (E/Z)-N,n-Didesmethyl-4-Hydroxy Tamoxifen 2'-Azide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95% (Area %)
E/Z Isomer Ratio	Specified on COA
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.