Description

tert-Butyl 5-Oxo-6,7-Dihydro-5H-Spiro[[1,6]Naphthyridine-8,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. This spirocyclic compound serves as a critical building block for the synthesis of complex molecules targeting a range of therapeutic areas. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those with spirocyclic or fused heterocyclic architectures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Protease Inhibitor Development: The structural motif is relevant for creating inhibitors targeting various protease enzymes.
• Kinase Inhibitor Scaffold: Serves as a core scaffold for the design and synthesis of potential kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	tert-Butyl 5-Oxo-6,7-Dihydro-5H-Spiro[[1,6]Naphthyridine-8,4'-Piperidine]-1'-Carboxylate
CAS No.	1330765-76-8
Molecular Formula	C17H23N3O3
Molecular Weight	317.38 g/mol
Synonyms	1'-Boc-5-oxo-6,7-dihydro-5H-spiro[[1,6]naphthyridine-8,4'-piperidine]; tert-Butyl 5-oxo-6,7-dihydrospiro[[1,6]naphthyridine-8,4'-piperidine]-1'-carboxylate; 1,6-Naphthyridine-8(5H)-one, 1,4,6,7-tetrahydro-4-(1,1-dimethylethoxy)carbonyl)spiro-; Spiro[[1,6]naphthyridine-8,4'-piperidine]-1'-carboxylic acid, 5-oxo-6,7-dihydro-, 1,1-dimethylethyl ester; 1330765-76-8; 1'-Boc-5-oxo-6,7-dihydrospiro[[1,6]naphthyridine-8,4'-piperidine]; Boc-protected spirocyclic naphthyridinone piperidine.
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Oxo-6,7-Dihydro-5H-Spiro[[1,6]Naphthyridine-8,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.