Description

tert-Butyl 7-(Aminomethyl)-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate (Wx100668) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value for medicinal chemistry research and development, offering a versatile building block for constructing complex molecular architectures. It is primarily sought after by R&D teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas.

Application

• Key Intermediate in API Synthesis: Serves as a critical building block in the multi-step synthesis of novel drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry & Lead Optimization: Used by research chemists to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Spirocyclic Compound Library Development: Essential for creating diverse screening libraries focused on spiroheterocycles, which are prized for their three-dimensionality and potential for novel bioactivity.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for potential commercial drug manufacturing.
• Contract Research & Development (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with outsourced R&D and manufacturing.

Basic Information

Product Name	tert-Butyl 7-(Aminomethyl)-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate (Wx100668)
CAS No.	1330765-27-9
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	2-[(tert-Butoxy)carbonyl]-5-oxa-2-azaspiro[3.4]octane-7-methanamine; 7-(Aminomethyl)-2-[(2-methyl-2-propanyl)oxycarbonyl]-5-oxa-2-azaspiro[3.4]octane; 5-Oxa-2-azaspiro[3.4]octane-7-methanamine, 2-(1,1-dimethylethyl) ester; Boc-protected 7-aminomethyl-5-oxa-2-azaspiro[3.4]octane; tert-Butyl 7-(aminomethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; WX-100668; Wx100668.
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-(Aminomethyl)-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the material under an inert atmosphere or in a desiccator for long-term preservation. Typical storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.