Description

2-tert-Butyl 5-Ethyl 3,4-Dihydro-2,7-Naphthyridine-2,5(1H)-Dicarboxylate CAS NO 1330764-93-6 is a high-purity, advanced pharmaceutical intermediate characterized by its complex naphthyridine-dicarboxylate structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting protein kinases and other enzymatic pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• API Development: Integral in the process development and scale-up stages for new Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery and development projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug design methodologies.

Basic Information

Product Name	2-tert-Butyl 5-Ethyl 3,4-Dihydro-2,7-Naphthyridine-2,5(1H)-Dicarboxylate
CAS No.	1330764-93-6
Molecular Formula	C17H24N2O4
Molecular Weight	320.39 g/mol
Synonyms	2-(tert-Butyl) 5-ethyl 3,4-dihydro-2,7-naphthyridine-2,5(1H)-dicarboxylate; 1,2,3,4-Tetrahydro-2,7-naphthyridine-2,5-dicarboxylic acid 2-(1,1-dimethylethyl) 5-ethyl ester; 5-Ethyl 2-tert-butyl 1,2,3,4-tetrahydro-2,7-naphthyridine-2,5-dicarboxylate; tert-Butyl 5-ethyl 1,2,3,4-tetrahydro-2,7-naphthyridine-2,5-dicarboxylate; 1330764-93-6; 2,7-Naphthyridine-2,5(1H)-dicarboxylic acid, 3,4-dihydro-, 2-(1,1-dimethylethyl) 5-ethyl ester
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Quality Control

Our 2-tert-Butyl 5-Ethyl 3,4-Dihydro-2,7-Naphthyridine-2,5(1H)-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider holding under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.