Description

5-Boc-5-Azaspiro[2.4]Heptane-1-Methamine is a high-value, protected amine building block featuring a unique spirocyclic structure. This compound is essential for medicinal chemistry research and development, serving as a key intermediate in the synthesis of novel pharmaceutical candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries to construct complex molecules targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in CNS drug discovery.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce constrained spirocyclic motifs.
• Peptidomimetics Synthesis: Employed to create conformationally restricted peptide analogs, enhancing metabolic stability and bioavailability.
• Ligand and Probe Development: Serves as a scaffold for developing chemical probes and ligands for biological target validation.
• Process Chemistry: Utilized in route scouting and scale-up synthesis for clinical trial material manufacturing.
• Library Synthesis: A valuable reagent for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Product Name	5-Boc-5-Azaspiro[2.4]Heptane-1-Methamine
CAS No.	1330764-37-8
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	1-[(tert-Butoxycarbonyl)amino]-5-azaspiro[2.4]heptane; tert-Butyl N-(5-azaspiro[2.4]heptan-1-yl)carbamate; 5-Azaspiro[2.4]heptane-1-methanamine, N-Boc-protected; Boc-5-Azaspiro[2.4]heptane-1-methylamine; 1-(Boc-amino)-5-azaspiro[2.4]heptane; 5-Boc-5-azaspiro[2.4]heptane-1-methylamine; 1-Amino-5-azaspiro[2.4]heptane, N-Boc derivative
EINECS	Contact for details

Quality Control

Our 5-Boc-5-Azaspiro[2.4]Heptane-1-Methamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.