Description

2-Boc-5-Hydroxy-2-Azaspiro[3.3]Heptane CAS NO 1330764-31-2 is a high-value, protected heterocyclic building block featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel, three-dimensional molecular architectures. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex active pharmaceutical ingredients (APIs) and chemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used to introduce constrained, three-dimensional spirocyclic motifs into lead compounds to improve potency, selectivity, and metabolic stability.
• Chemical Biology: Serves as a building block for creating molecular probes and tool compounds to study biological pathways and protein function.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for advanced pharmaceutical intermediates.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.
• Library Synthesis: Used in the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery campaigns.

Basic Information

Product Name	2-Boc-5-Hydroxy-2-Azaspiro[3.3]Heptane
CAS No.	1330764-31-2
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	tert-Butyl 5-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate; 2-(tert-Butoxycarbonyl)-5-hydroxy-2-azaspiro[3.3]heptane; 5-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; 2-Boc-2-azaspiro[3.3]heptan-5-ol; 2-Azaspiro[3.3]heptan-5-ol, 2-(1,1-dimethylethoxy)carbonyl]-; 1330764-31-2; Boc-protected 2-azaspiro[3.3]heptan-5-ol
EINECS	Contact for details

Quality Control

Our 2-Boc-5-Hydroxy-2-Azaspiro[3.3]Heptane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.