Description

tert-Butyl 7-(Hydroxymethyl)-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile handle for further chemical elaboration. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for the construction of novel drug candidates, particularly in areas like protease inhibitors and other small-molecule therapeutics.

Application

• Key Intermediate in Drug Discovery: Serves as a crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Protease Inhibitor Development: Its structural motif is highly relevant for constructing potent inhibitors of proteolytic enzymes, a major class of therapeutic targets.
• Spirocyclic Compound Library Synthesis: Used in medicinal chemistry for generating diverse compound libraries to explore new chemical space and identify lead structures.
• Peptidomimetic Research: Acts as a scaffold for developing peptidomimetics, which are designed to mimic peptides but with improved stability and bioavailability.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for candidate drugs during later-stage R&D.

Basic Information

Product Name	tert-Butyl 7-(Hydroxymethyl)-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate
CAS No.	1330764-06-1
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	2-[(tert-Butoxy)carbonyl]-5-oxa-2-azaspiro[3.4]octan-7-ylmethanol; tert-Butyl 7-(hydroxymethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; 7-(Hydroxymethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; Boc-Protected 7-Hydroxymethyl-5-Oxa-2-Azaspiro[3.4]Octane; Spirocyclic Boc-Amino Alcohol Ester; 1330764-06-1; 5-Oxa-2-azaspiro[3.4]octane-2-carboxylic acid, 7-(hydroxymethyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-(Hydroxymethyl)-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full analytical data is provided with every shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.