Description

8-Boc-1-Oxa-8-Azaspiro[4.5]Decane-3-Methanol is a high-purity, advanced pharmaceutical intermediate featuring a protected spirocyclic amine structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel drug candidates targeting central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for clinical and commercial manufacturing.
• Spirocyclic Compound Library Synthesis: Essential for constructing diverse compound libraries featuring the privileged 1-oxa-8-azaspiro[4.5]decane scaffold for high-throughput screening.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for the secondary amine, enabling complex multi-step syntheses.
• Chemical Biology Probes: Can be utilized to create tool compounds and probes for investigating biological pathways and target engagement.

Basic Information

Product Name	8-Boc-1-Oxa-8-Azaspiro[4.5]Decane-3-Methanol
CAS No.	1330763-99-9
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	3-(Hydroxymethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; tert-Butyl 3-(hydroxymethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 8-(tert-Butoxycarbonyl)-1-oxa-8-azaspiro[4.5]decane-3-methanol; 1-Oxa-8-azaspiro[4.5]decane-3-methanol, 8-Boc-protected; Boc-1-Oxa-8-Azaspiro[4.5]decane-3-Methanol
EINECS	Contact for details

Quality Control

Our 8-Boc-1-Oxa-8-Azaspiro[4.5]Decane-3-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided for every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.