Description

(Trans)-4-(3-Pyridinyl)-Pyrrolidine-3-Carboxylic Acid-2Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining pyridine and pyrrolidine motifs. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) agents, enzyme inhibitors, and other therapeutic candidates. The dihydrochloride salt form enhances its stability and solubility for synthetic applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Ligand Synthesis: Used in the preparation of complex ligands for catalysis or biochemical probing.
• Chemical Biology Probes: Employed in the development of molecular tools to study biological pathways and protein function.
• Academic & Industrial R&D: Fundamental building block for exploratory synthetic chemistry and process development.

Basic Information

Item	Detail
Product Name	(Trans)-4-(3-Pyridinyl)-Pyrrolidine-3-Carboxylic Acid-2Hcl
CAS No.	1330750-18-9
Molecular Formula	C10H14N2O2 • 2HCl
Molecular Weight	279.16 g/mol (Free base: 194.23 g/mol)
Synonyms	(3R,4S)-4-(Pyridin-3-yl)pyrrolidine-3-carboxylic acid dihydrochloride; (3R,4S)-4-(3-Pyridyl)pyrrolidine-3-carboxylic acid hydrochloride (1:2); trans-4-(3-Pyridyl)pyrrolidine-3-carboxylic acid dihydrochloride; 4-(Pyridin-3-yl)pyrrolidine-3-carboxylic acid 2HCl; (3R,4S)-4-(3-Pyridinyl)-3-pyrrolidinecarboxylic acid dihydrochloride; (3R,4S)-4-(3-Pyridyl)-3-pyrrolidinecarboxylic acid 2HCl
EINECS	Contact for details

Quality Control

Our production of (Trans)-4-(3-Pyridinyl)-Pyrrolidine-3-Carboxylic Acid-2Hcl adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under dry, inert conditions to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.