Description

Ald-Peg4-Pfp CAS NO 1324007-10-4 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an aldehyde group and a pentafluorophenyl (PFP) ester, designed for advanced bioconjugation and material science applications. This compound is critical for creating stable, site-specific linkages between amine-containing molecules and hydroxyl or amine groups under mild conditions. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and the synthesis of functionalized biomaterials and hydrogels.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of drugs, peptides, or fluorescent dyes to antibodies, proteins, or other biomolecules.
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to enhance solubility, stability, and circulation time of therapeutic proteins and peptides.
• Surface Functionalization: Modification of nanoparticles, biosensors, and diagnostic assay surfaces with bioactive ligands.
• Hydrogel and Biomaterial Synthesis: Crosslinking agent for creating biocompatible scaffolds for tissue engineering and drug delivery systems.
• Polymer Chemistry: Building block for synthesizing functionalized block copolymers and smart materials.
• Diagnostic Reagent Manufacturing: Production of labeled antigens, antibodies, and other components for immunoassays.

Basic Information

Item	Detail
Product Name	Ald-Peg4-Pfp
CAS No.	1324007-10-4
Molecular Formula	C₂₃H₂₈F₅NO₈
Molecular Weight	541.47 g/mol
Synonyms	4-((2-(2-(2-(2-(2,3,5,6-Tetrafluoro-4-formylphenoxy)ethoxy)ethoxy)ethoxy)ethoxy)methyl)benzoic acid 2,3,5,6-tetrafluorophenyl ester; Aldehyde-PEG4-PFP ester; Fmoc-PEG4-CHO PFP ester (precursor); α-Aldehyde-ω-PFP-PEG4; PFP-PEG4-CHO; 2,3,5,6-Tetrafluorophenyl 4-((2-(2-(2-(2-(2-(2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethoxy)ethoxy)ethoxy)ethoxy)methyl)benzoate (related structure); Pentafluorophenyl-PEG4-aldehyde
EINECS	Contact for details

Quality Control

Our Ald-Peg4-Pfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, supporting our commitment to supplying reagents suitable for preclinical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. For long-term storage, desiccate at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.