Description

Methyl 2-(Bromomethyl)-3-((tert-Butyldimethylsilyl)Oxy)Benzoate is a sophisticated, multi-functional organic building block featuring both a bromomethyl electrophile and a protected phenolic hydroxyl group. This compound matters for its critical role in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists for constructing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials, where its reactive handles enable precise and sequential chemical modifications.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, particularly those containing benzofuran or substituted benzyl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators requiring specific aromatic ether linkages.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes (ABPs) and molecular tags for studying enzyme function and protein interactions.
• Academic & Contract Research: Essential for methodology development in organic synthesis, including palladium-catalyzed cross-coupling and nucleophilic substitution reactions.
• Custom Synthesis & Scale-Up: A starting material for contract manufacturing organizations (CMOs) producing high-value, low-volume specialty chemicals for clients.

Basic Information

Product Name	Methyl 2-(Bromomethyl)-3-((tert-Butyldimethylsilyl)Oxy)Benzoate
CAS No.	1323407-17-5
Molecular Formula	C15H23BrO3Si
Molecular Weight	359.34 g/mol
Synonyms	Methyl 2-(bromomethyl)-3-[(tert-butyldimethylsilyl)oxy]benzoate; Benzoic acid, 2-(bromomethyl)-3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, methyl ester; 2-(Bromomethyl)-3-(tert-butyldimethylsilyloxy)methyl benzoate; Methyl 3-(TBDMSO)-2-(bromomethyl)benzoate; 3-(tert-Butyldimethylsilyloxy)-2-bromomethyl methyl benzoate; TBDMS-protected 2-bromomethyl-3-hydroxybenzoate methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-(Bromomethyl)-3-((tert-Butyldimethylsilyl)Oxy)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate to minimize degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.