Description

4-Chloro-3,5-Dimethylpicolinonitrile is a high-value, halogenated pyridine derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both chloro and cyano substituents on the dimethylpyridine ring, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand and Catalyst Development: Used to create novel pyridine-based ligands for transition metal catalysis in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Intermediate for synthesizing functional organic materials, including liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes and inhibitors for biochemical and pharmacological research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	4-Chloro-3,5-Dimethylpicolinonitrile
CAS No.	1323392-95-5
Molecular Formula	C8H7ClN2
Molecular Weight	166.61 g/mol
Synonyms	4-Chloro-3,5-dimethylpyridine-2-carbonitrile; 2-Cyano-4-chloro-3,5-dimethylpyridine; 3,5-Dimethyl-4-chloropicolinonitrile; 4-Chloro-3,5-dimethyl-2-pyridinecarbonitrile; 4-Chloro-3,5-dimethyl-2-cyanopyridine; Picolinonitrile, 4-chloro-3,5-dimethyl-; 1323392-95-5
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Dimethylpicolinonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, GC, NMR, and mass spectrometry. Our quality commitment ensures the material meets the stringent requirements for research and development as well as scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.