Description

tert-Butyl 6-Hydroxy-2-Azaspiro[4.4]Nonane-2-Carboxylate (Wx101381) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and heterocyclic structure. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is primarily sought by pharmaceutical R&D laboratories and custom synthesis organizations engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates targeting neurological pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a crucial chiral building block for constructing sophisticated molecular architectures in final active pharmaceutical ingredients.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for scale-up and cGMP production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for studying novel organic reactions and synthetic methodologies involving spiro compounds.
• Bioconjugation & Probe Development: The hydroxyl and carboxylate-protected functional groups offer handles for further chemical modification in developing diagnostic probes.

Basic Information

Product Name	tert-Butyl 6-Hydroxy-2-Azaspiro[4.4]Nonane-2-Carboxylate (Wx101381)
CAS No.	1319716-44-3
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	2-Azaspiro[4.4]nonane-2-carboxylic acid, 6-hydroxy-, 1,1-dimethylethyl ester; 6-Hydroxy-2-azaspiro[4.4]nonane-2-carboxylic acid tert-butyl ester; tert-Butyl 6-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate; WX-101381; Wx101381; BOC-6-Hydroxy-2-azaspiro[4.4]nonane; 6-Hydroxy-2-(tert-butoxycarbonyl)-2-azaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Hydroxy-2-Azaspiro[4.4]Nonane-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity and structural integrity, meeting the exacting standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.