Description

7-Hydroxy-2-Aza-Spiro[4.4]Nonane-2-Carboxylic Acid tert-Butyl Ester is a sophisticated spirocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules. Pharmaceutical R&D and fine chemical manufacturers need this high-purity intermediate to construct constrained molecular architectures, particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in neurological and psychiatric therapeutic areas.
• Protease Inhibitor Scaffold: Serves as a core structural element in the design and development of protease inhibitors due to its constrained spirocyclic geometry.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore novel pharmacophores and improve drug-like properties.
• Asymmetric Synthesis: Employed as a building block in stereoselective synthesis to introduce complex chiral centers into target molecules.
• Peptidomimetic Development: Integral for creating peptidomimetics where the spiro structure mimics peptide turn conformations.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical innovation from discovery to development.

Basic Information

Item	Details
Product Name	7-Hydroxy-2-Aza-Spiro[4.4]Nonane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1319716-41-0
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	tert-Butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate; 2-Azaspiro[4.4]nonane-2-carboxylic acid, 7-hydroxy-, 1,1-dimethylethyl ester; 7-Hydroxy-2-aza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester; 2-Aza-spiro[4.4]nonane-2-carboxylic acid, 7-hydroxy-, tert-butyl ester; 2-tert-Butoxycarbonyl-7-hydroxy-2-azaspiro[4.4]nonane; BOC-7-Hydroxy-2-azaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our 7-Hydroxy-2-Aza-Spiro[4.4]Nonane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.