Description

6-(Hydroxymethyl)Pyridine-2-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a key building block in modern synthetic chemistry. Its bifunctional structure, featuring both a hydroxymethyl group and a protected boronic acid, makes it a versatile intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for applications in Suzuki-Miyaura cross-coupling reactions and the synthesis of novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to create novel pesticides and herbicides with enhanced efficacy and selectivity.
• Material Science: Serves as a monomer or linker in the development of advanced polymers, ligands for catalysis, and organic electronic materials.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura cross-coupling to form carbon-carbon bonds, enabling the construction of biaryl and other complex aromatic systems.
• Chemical Biology & Diagnostics: Utilized in the development of molecular probes, sensors, and bioconjugates due to its reactive handles.
• Ligand Synthesis: Acts as a building block for creating sophisticated chiral and achiral ligands used in asymmetric catalysis.

Basic Information

Product Name	6-(Hydroxymethyl)Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	1315350-82-3
Molecular Formula	C13H20BNO3
Molecular Weight	249.12 g/mol
Synonyms	2-(6-(Hydroxymethyl)pyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 6-(Hydroxymethyl)-2-pyridineboronic acid pinacol ester; (6-(Hydroxymethyl)pyridin-2-yl)boronic acid pinacol ester; 2-(6-(Hydroxymethyl)-2-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol 6-(hydroxymethyl)pyridine-2-boronate
EINECS	Contact for details

Quality Control

Our 6-(Hydroxymethyl)Pyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.