Description

4-Amino-3-Cyano-2-(Trifluoromethyl)Quinolin-6-Ylboronic Acid is a highly functionalized, advanced pharmaceutical intermediate and building block for organic synthesis. Its value lies in the unique combination of a boronic acid group, a quinoline core, and trifluoromethyl and cyano substituents, enabling precise cross-coupling reactions and the introduction of complex molecular architectures. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting oncology and central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functional group makes it a critical reagent for forming carbon-carbon bonds to construct biaryl structures common in modern pharmaceuticals.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a precursor for creating organic electronic materials and metal-organic frameworks (MOFs) with specialized properties.
• Chemical Biology & Proteomics: Employed as a molecular probe or linker in the study of biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	4-Amino-3-Cyano-2-(Trifluoromethyl)Quinolin-6-Ylboronic Acid
CAS No.	1315335-66-0
Molecular Formula	C₁₁H₇BF₃N₃O₂
Molecular Weight	281.00 g/mol
Synonyms	6-Borono-4-amino-3-cyano-2-(trifluoromethyl)quinoline; 4-Amino-3-cyano-2-(trifluoromethyl)-6-quinolineboronic acid; 2-(Trifluoromethyl)-4-amino-3-cyanoquinolin-6-ylboronic acid; (4-Amino-3-cyano-2-(trifluoromethyl)quinolin-6-yl)boronic acid; Quinolin-6-ylboronic acid, 4-amino-3-cyano-2-(trifluoromethyl)-; B-[4-Amino-3-cyano-2-(trifluoromethyl)-6-quinolinyl]boronic acid
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Cyano-2-(Trifluoromethyl)Quinolin-6-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.