Description

6'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopentane-1,4'-Isoquinoline] is a high-value, structurally complex organic compound featuring a spirocyclic framework and a trifluoromethyl group, making it a versatile building block for advanced chemical synthesis. Its unique architecture is prized for modulating the physicochemical properties of target molecules, particularly in enhancing metabolic stability and lipophilicity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the design and synthesis of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Material Science Research: Serves as a specialized monomer or additive in the development of advanced polymers and organic electronic materials.
• Chemical Biology Probe: Employed as a scaffold for developing molecular probes to study enzyme function and biological pathways.
• Catalyst Ligand Development: The spirocyclic structure can be utilized to create novel chiral ligands for asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	6'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopentane-1,4'-Isoquinoline]
CAS No.	1314781-66-2
Molecular Formula	C14H16F3N
Molecular Weight	255.28 g/mol
Synonyms	1'H-Spiro[cyclopentane-1,4'-isoquinoline], 6'-(trifluoromethyl)-2',3'-dihydro-; 6-(Trifluoromethyl)-1,2,3,4-tetrahydrospiro[isoquinoline-4,1'-cyclopentane]; Spiro[cyclopentane-1,4'-isoquinoline], 6'-(trifluoromethyl)-2',3'-dihydro-; 1314781-66-2; 6'-Trifluoromethyl-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-isoquinoline]; 6-(Trifluoromethyl)-2,3-dihydro-1H-spiro[isoquinoline-4,1'-cyclopentane]
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our advanced intermediates. Each batch of 6'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopentane-1,4'-Isoquinoline] is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive analytical results from techniques including HPLC, NMR, and MS are provided with every shipment. Our quality system supports development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.