Description

6'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclobutane-1,4'-Isoquinoline] is a sophisticated spirocyclic compound featuring a trifluoromethyl group, a structural motif of high value in modern organic synthesis. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block for the development of novel bioactive molecules. It is primarily needed by pharmaceutical R&D and agrochemical research teams focused on creating new drug candidates and crop protection agents with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the stability and lipophilicity imparted by the trifluoromethyl and spirocyclic groups.
• Material Science: Exploration of applications in organic electronics and advanced polymers, where its unique rigid structure can influence material properties.
• Chemical Biology Probe: Serves as a scaffold for developing molecular probes to study enzyme function and biological pathways.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies and lead optimization programs to improve pharmacokinetic profiles.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	6'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclobutane-1,4'-Isoquinoline]
CAS No.	1314779-29-7
Molecular Formula	C₁₃H₁₂F₃N
Molecular Weight	239.24 g/mol
Synonyms	1'H-Spiro[cyclobutane-1,4'-isoquinoline], 6'-(trifluoromethyl)-2',3'-dihydro-; 6-(Trifluoromethyl)-1,2,3,4-tetrahydrospiro[isoquinoline-4,1'-cyclobutane]; Spiro[cyclobutane-1,4'-isoquinoline], 6'-(trifluoromethyl)-2',3'-dihydro-; 1314779-29-7; 6'-(Trifluoromethyl)-2',3'-dihydrospiro[cyclobutane-1,1'-isoquinoline]; 6-(Trifluoromethyl)-2,3-dihydro-1H-spiro[isoquinoline-4,1'-cyclobutane]; 6-Trifluoromethyl-1,2,3,4-tetrahydrospiro[isoquinoline-4,1'-cyclobutane]
EINECS	Contact for details

Quality Control

Our production of 6'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclobutane-1,4'-Isoquinoline] adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing all critical parameters are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.