Description

8'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopentane-1,4'-Isoquinoline] is a sophisticated spirocyclic organic compound featuring a trifluoromethyl group, a structural motif of high interest in modern medicinal and agrochemical research. This compound serves as a versatile and valuable building block for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced materials. It is primarily sought after by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers engaged in developing new molecules with enhanced biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used as a precursor for novel herbicides, fungicides, and insecticides, leveraging the stability imparted by the trifluoromethyl group.
• Material Science Research: Serves as a building block for advanced organic materials, including liquid crystals and organic light-emitting diodes (OLEDs).
• Chemical Biology Probe Development: Employed in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Catalyst Ligand Synthesis: Potential use in the creation of novel chiral ligands for asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring complex, fluorinated spirocyclic architectures.

Basic Information

Product Name	8'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopentane-1,4'-Isoquinoline]
CAS No.	1314709-76-6
Molecular Formula	C14H16F3N
Molecular Weight	255.28 g/mol
Synonyms	1'H-Spiro[cyclopentane-1,4'-isoquinoline], 8'-(trifluoromethyl)-2',3'-dihydro-; 8-(Trifluoromethyl)-1,2,3,4-tetrahydrospiro[isoquinoline-4,1'-cyclopentane]; Spiro[cyclopentane-1,4'-isoquinoline], 8'-(trifluoromethyl)-2',3'-dihydro-; 1314709-76-6; 8'-Trifluoromethyl-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-isoquinoline]; 8'-(Trifluoromethyl)-1,2,3,4-tetrahydrospiro[isoquinoline-4,1'-cyclopentane]; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 8'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopentane-1,4'-Isoquinoline] is produced under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for GMP-grade intermediates and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.