Description

Di-T-Butylisobutylsilyl Trifluoromethanesulfonate is a highly reactive silylating agent and protecting group reagent used in advanced organic synthesis. Its core value lies in its ability to introduce the bulky di-tert-butylisobutylsilyl (DTBIS) group, offering superior steric protection for sensitive functional groups like alcohols and amines under demanding reaction conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for complex molecule construction, including natural products and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate Synthesis: As a key protecting group reagent for hydroxyl and amino functions in the multi-step synthesis of complex drug candidates and APIs.
• Natural Product and Peptide Chemistry: For the selective protection of sensitive alcohol groups during the synthesis of steroids, carbohydrates, and complex peptides.
• Agrochemical Research: Used in the development and scale-up of novel pesticides and herbicides where robust protecting groups are required.
• Material Science Precursor: Acts as a silylating agent in the surface modification of silica and other materials to impart specific organic functionalities.
• Asymmetric Synthesis: Employed in chiral auxiliary and catalyst design where temporary, bulky protection is needed to control stereoselectivity.
• Process Chemistry & Scale-Up: Suitable for kilogram-scale production in GMP or non-GMP environments for commercial manufacturing routes.

Basic Information

Item	Details
Product Name	Di-T-Butylisobutylsilyl Trifluoromethanesulfonate
CAS No.	1314639-86-5
Molecular Formula	C13H27F3O3SSi
Molecular Weight	348.50 g/mol
Synonyms	DTBIS Triflate; Di-tert-butylisobutylsilyl Triflate; Di-tert-butyl(isobutyl)silyl Trifluoromethanesulfonate; (Isobutyl)di-tert-butylsilyl Triflate; 1,1-Dimethylethyl[[(1,1-dimethylethyl)(2-methylpropyl)silyl]oxy]sulfonyl-difluoromethane; Trifluoromethanesulfonic Acid Di-tert-butylisobutylsilyl Ester
EINECS	Contact for details

Quality Control

Our Di-T-Butylisobutylsilyl Trifluoromethanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by NMR, HPLC), identity confirmation, and impurity profiles. Our quality system is designed to support cGMP compliance for pharmaceutical development, and we can accommodate custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) when not in use. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.