Description

Alpha, ω-Disuccinimidyl Diethylene Glycol is a heterobifunctional, amine-reactive crosslinking agent featuring an extended hydrophilic spacer arm. This compound is engineered to facilitate the conjugation of biomolecules, offering superior control over reaction specificity and linkage length. It is an essential reagent for researchers and manufacturers in bioconjugation, diagnostics development, and advanced material sciences who require reliable, high-purity building blocks for creating stable molecular assemblies.

Application

• Bioconjugation and Protein Labeling: For covalently linking proteins, antibodies, or peptides to other molecules, surfaces, or carriers.
• Diagnostic Assay Development: Used in the fabrication of enzyme-linked immunosorbent assays (ELISA), lateral flow tests, and other immunoassay components.
• Polymer and Biomaterial Synthesis: Serves as a crosslinker for creating hydrogels, functionalized polymers, and drug delivery systems with tailored properties.
• Immobilization Chemistry: For attaching biomolecules to solid supports such as beads, chips, and sensor surfaces for analytical or purification purposes.
• Antibody-Drug Conjugate (ADC) Research: A key intermediate in the development of linker-payload constructs for targeted cancer therapies.
• Nucleic Acid Modification: Enabling the attachment of reporter groups or other functional moieties to oligonucleotides.

Basic Information

Product Name	Alpha, ω-Disuccinimidyl Diethylene Glycol
CAS No.	1314378-16-9
Molecular Formula	C16H20N2O10
Molecular Weight	400.34 g/mol
Synonyms	Disuccinimidyl Diethylene Glycol; Diethylene Glycol bis(succinimidyl succinate); DSS Crosslinker analog; NHS-PEG2-NHS; Bis(N-succinimidyl) PEG2 ester; Succinimidyl PEG2 Succinimidyl ester; PEG2-dNHS; 1,11-Bis[(2,5-dioxo-1-pyrrolidinyl)oxy]-3,6,9-trioxaundecane-1,11-dione
EINECS	Contact for details

Quality Control

Our Alpha, ω-Disuccinimidyl Diethylene Glycol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for research and bioprocessing. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.