Description

4-(Tetrahydro-2H-Pyran-2-Yl)Methoxyphenylboronic Acid is a sophisticated boronic acid derivative featuring a tetrahydropyran-protected phenol group, making it a valuable building block in modern synthetic chemistry. Its primary value lies in its role as a key intermediate in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require high-purity, functionalized intermediates for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex aromatic scaffolds.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific biaryl motifs for enhanced activity.
• Material Science & OLED Development: Serves as a precursor for organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in OLED devices.
• Ligand & Catalyst Preparation: Employed in the development of novel ligands for transition metal catalysts used in asymmetric synthesis.
• Chemical Biology & Probe Synthesis: Utilized for creating molecular probes and bioconjugates due to its boronic acid functionality, which can interact with diols.
• Academic & Contract Research: A staple reagent in research laboratories for methodological development and the construction of complex molecular libraries.

Basic Information

Product Name	4-(Tetrahydro-2H-Pyran-2-Yl)Methoxyphenylboronic Acid
CAS No.	1313761-97-5
Molecular Formula	C₁₂H₁₇BO₄
Molecular Weight	236.07 g/mol
Synonyms	[4-(Oxan-2-yloxy)phenyl]boronic acid; 4-(2-Tetrahydropyranyloxy)phenylboronic Acid; 4-(THP-O)C6H4B(OH)2; 4-(Tetrahydro-2H-pyran-2-yloxy)benzeneboronic acid; B-[4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenyl]boronic acid; 4-(2H-Pyran-2-yloxy)phenylboronic acid, tetrahydro-; THP-Protected 4-Hydroxyphenylboronic Acid
EINECS	Contact for details

Quality Control

Our 4-(Tetrahydro-2H-Pyran-2-Yl)Methoxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for cGMP intermediates and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.