Description

Resiquimod Hydrochloride is a potent synthetic immune response modifier belonging to the imidazoquinoline amine family. This compound is of significant commercial and research interest due to its role as a selective agonist for Toll-like receptors 7 and 8 (TLR7/8), which are key mediators of innate and adaptive immunity. It is primarily utilized by pharmaceutical R&D teams and manufacturers engaged in the development of novel immunotherapies, antiviral agents, and vaccine adjuvants. The material is supplied as a high-purity active pharmaceutical ingredient (API) to support critical preclinical and clinical studies.

Application

• Immunotherapy Research: As a TLR7/8 agonist for investigating immune system activation pathways and developing treatments for cancers, viral infections, and autoimmune diseases.
• Vaccine Adjuvant Development: Used in research to enhance the efficacy of prophylactic and therapeutic vaccines by potentiating cellular immune responses.
• Dermatological Formulations: A key ingredient in clinical studies for topical treatments targeting conditions like actinic keratosis, basal cell carcinoma, and genital warts.
• Antiviral Drug Discovery: Serves as a lead compound or reference standard in the search for new agents against viruses such as HPV and HSV.
• Biochemical & Pharmacological Studies: Employed as a precise tool to study TLR signaling mechanisms, cytokine induction, and dendritic cell maturation in vitro.
• Pharmaceutical Intermediates: Used in the synthesis of more complex immunomodulatory agents or prodrugs.

Basic Information

Item	Detail
Product Name	Resiquimod Hydrochloride
CAS No.	1313757-36-6
Molecular Formula	C17H22N4O2 • HCl
Molecular Weight	350.84 g/mol (Hydrochloride salt)
Synonyms	R-848 Hydrochloride; S-28463 Hydrochloride; 4-Amino-2-(ethoxymethyl)-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol Hydrochloride; Resiquimod HCl; TLR7/8 Agonist R-848 HCl; Imiquimod analog R-848; 1-(4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol Hydrochloride
EINECS	Contact for details

Quality Control

Our Resiquimod Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research and development purposes. Each lot is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling using advanced techniques like HPLC and mass spectrometry. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring the material meets the stringent requirements of preclinical and clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, ideally between 15°C and 25°C (59°F and 77°F). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or storage under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.