Description

6-Bromo-1-(2-Trimethylsilanyl-Ethoxymethyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridine is a high-value, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for medicinal chemistry research and development, offering a protected and reactive scaffold for constructing novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in oncology, antiviral, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel triazolopyridine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: A precursor for developing potent and selective kinase inhibitors due to the triazolopyridine core.
• Agrochemical Research: Intermediate for developing new crop protection agents and pesticides.
• Material Science: Potential monomer or precursor for functional polymers and advanced organic electronic materials.

Basic Information

Item	Details
Product Name	6-Bromo-1-(2-Trimethylsilanyl-Ethoxymethyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridine
CAS No.	1313712-18-3
Molecular Formula	C12H19BrN4OSi
Molecular Weight	359.30 g/mol
Synonyms	6-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine; 6-Bromo-1-(2-trimethylsilylethoxymethyl)-1H-[1,2,3]triazolo[4,5-b]pyridine; 6-Bromo-1-SEM-1H-[1,2,3]triazolo[4,5-b]pyridine; 6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyridine, 1-[(2-(trimethylsilyl)ethoxy)methyl]-; 1313712-18-3; SEM-protected 6-bromotriazolopyridine; 6-Br-1-SEM-Triazolo[4,5-b]pyridine
EINECS	Contact for details

Quality Control

Our 6-Bromo-1-(2-Trimethylsilanyl-Ethoxymethyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The container should be kept sealed to protect from moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.