Description

Methyl cis-3-(Boc-Amino)-2,2-Dimethylcyclobutanecarboxylate is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a sterically hindered, conformationally constrained cyclobutane scaffold with orthogonal protecting groups, enabling precise molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for complex small molecule APIs and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors, kinase inhibitors, and other therapeutics requiring constrained peptide backbones.
• Peptidomimetics Research: Used to incorporate rigid, non-natural amino acid motifs into peptide chains to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Serves as a precursor for developing new generation pesticides and herbicides with improved selectivity and environmental profile.
• Chemical Biology & Probe Development: Employed in the creation of activity-based probes and molecular tools for studying enzyme function and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Potential use in the synthesis of novel chiral ligands and organocatalysts for stereoselective transformations.
• Material Science: Building block for specialty polymers and advanced materials requiring specific stereochemistry and functional groups.

Basic Information

Product Name	Methyl cis-3-(Boc-Amino)-2,2-Dimethylcyclobutanecarboxylate
CAS No.	1313358-57-4
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	Methyl (1S,3R)-3-[(tert-Butoxycarbonyl)amino]-2,2-dimethylcyclobutanecarboxylate; cis-Methyl 3-(Boc-amino)-2,2-dimethylcyclobutanecarboxylate; (1S,3R)-Methyl 3-((tert-butoxycarbonyl)amino)-2,2-dimethylcyclobutanecarboxylate; Boc-ACBC-OMe; Boc-3-Amino-2,2-dimethylcyclobutanecarboxylic Acid Methyl Ester (cis); tert-Butyl ((1S,3R)-3-(methoxycarbonyl)-2,2-dimethylcyclobutyl)carbamate; Protected 3-Amino-2,2-dimethylcyclobutanecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl cis-3-(Boc-Amino)-2,2-Dimethylcyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and impurity profiling, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with full chromatographic data are provided for every shipment, and we support custom purity and packaging specifications for scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.