Description

Boc-N-Me-Ser(Tbu)-OH is a protected, non-proteinogenic amino acid derivative of significant importance in advanced organic synthesis. This compound is specifically engineered for the controlled construction of complex peptide chains, offering enhanced stability and selectivity during coupling reactions. It is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of peptides on resin supports.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins in solution, especially where specific side-chain protection is required.
• Pharmaceutical Research & Development: Serves as a crucial building block in the discovery and development of new peptide drugs, hormone analogs, and diagnostic agents.
• Synthesis of Modified Peptides: Enables the incorporation of N-methyl-serine residues into peptide sequences, which can enhance metabolic stability, membrane permeability, and biological activity.
• Combinatorial Chemistry Libraries: Used to generate diverse libraries of peptide-like compounds for high-throughput screening in drug discovery.
• Bioconjugation and Labeling: The protected functional groups allow for selective deprotection and subsequent conjugation with labels, tags, or other biomolecules.

Basic Information

Product Name	Boc-N-Me-Ser(Tbu)-OH
CAS No.	1313054-71-5
Molecular Formula	C₁₃H₂₅NO₅
Molecular Weight	275.34 g/mol
Synonyms	(2S)-3-[(2-Methylpropan-2-yl)oxy]-2-[(2-methylpropan-2-yl)oxycarbonyl(methyl)amino]propanoic acid; N-[(tert-Butoxy)carbonyl]-N-methyl-O-(tert-butyl)-L-serine; Boc-N-methyl-O-tert-butyl-L-serine; Boc-N-Me-Ser(OtBu)-OH; N-Boc-N-methyl-O-t-butyl-L-serine; (S)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-(tert-butoxy)propanoic acid; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, 3-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Boc-N-Me-Ser(Tbu)-OH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.