Description

2-{1-[3-(T-Butyldimethylsilyloxy)Propyl]Indole-3-Yl}Acetonitrile CAS NO 1312995-87-1 is a sophisticated, high-purity indole derivative featuring a tert-butyldimethylsilyl (TBDMS) protecting group. This compound is a critical advanced pharmaceutical intermediate (API intermediate) valued for its role in constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical development teams working on novel therapeutic agents, particularly in oncology and neurology.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, particularly those with indole-based core structures.
• Organic Synthesis Research: Used in academic and industrial R&D for developing new synthetic methodologies and exploring structure-activity relationships (SAR).
• Protecting Group Chemistry: The TBDMS-protected hydroxyl group allows for selective reactions at other sites on the molecule during multi-step synthesis.
• Precursor for Biologically Active Molecules: Acts as a precursor for the synthesis of potential serotonin receptor modulators and kinase inhibitors.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.

Basic Information

Product Name	2-{1-[3-(T-Butyldimethylsilyloxy)Propyl]Indole-3-Yl}Acetonitrile
CAS No.	1312995-87-1
Molecular Formula	C19H28N2OSi
Molecular Weight	328.53 g/mol
Synonyms	2-[1-[3-[(tert-Butyldimethylsilyl)oxy]propyl]-1H-indol-3-yl]acetonitrile; 2-(1-(3-((tert-Butyldimethylsilyl)oxy)propyl)-1H-indol-3-yl)acetonitrile; TBDMS-protected Indole-3-acetonitrile Derivative; 1-[3-(tert-Butyldimethylsiloxy)propyl]indole-3-acetonitrile; 3-(Cyanomethyl)-1-[3-[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-1H-indole
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Our quality assurance includes comprehensive analytical testing via HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.