Description

(3S,5R)-tert-Butyl 3-Amino-5-(Trifluoromethyl)Piperidine-1-Carboxylate is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in the unique combination of a protected amine and a trifluoromethyl group, enabling the introduction of fluorine-based properties into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with improved metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of small molecule drugs, especially in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the trifluoromethyl group enhances biological activity.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes and enzyme inhibitors to study biological pathways.
• Material Science Research: Serves as a precursor for specialty chemicals and advanced materials requiring fluorinated components.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality starting material for optimizing synthetic routes from laboratory to pilot plant scale.
• Custom Synthesis & Contract Manufacturing: A fundamental component for companies offering bespoke chemical synthesis services for clients in regulated industries.

Basic Information

Product Name	(3S,5R)-tert-Butyl 3-Amino-5-(Trifluoromethyl)Piperidine-1-Carboxylate
CAS No.	1312810-30-2
Molecular Formula	C11H19F3N2O2
Molecular Weight	268.28 g/mol
Synonyms	1-Boc-3-amino-5-(trifluoromethyl)piperidine (stereoisomer); tert-Butyl 3-amino-5-(trifluoromethyl)piperidine-1-carboxylate; (3S,5R)-1-(tert-Butoxycarbonyl)-5-(trifluoromethyl)piperidin-3-amine; 1-N-Boc-3-amino-5-trifluoromethylpiperidine; 3-Amino-5-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester; BOC-3-Amino-5-CF3-piperidine; (3S,5R)-3-Amino-5-trifluoromethyl-piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of (3S,5R)-tert-Butyl 3-Amino-5-(Trifluoromethyl)Piperidine-1-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment. Our quality system is designed to support development under current Good Manufacturing Practice (cGMP) guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.