Description

(8α,9S)-10,11-Dihydro-9-Isocyano-6'-Methoxy-Cinchonan CAS NO 1312706-37-8 is a specialized, high-purity cinchona alkaloid derivative featuring a reactive isocyano functional group. This compound is of significant value as a key chiral intermediate or ligand in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily required by research institutions, pharmaceutical R&D laboratories, and advanced chemical synthesis facilities focused on developing novel therapeutic agents and high-value specialty molecules.

Application

• Asymmetric Catalysis: Serving as a chiral ligand or catalyst precursor in transition metal-catalyzed reactions such as hydrogenation, hydroxylation, and cycloaddition.
• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly those with complex stereocenters.
• Organocatalysis: Utilization as a chiral organocatalyst in carbon-carbon and carbon-heteroatom bond-forming reactions under metal-free conditions.
• Chemical Research: A valuable tool compound for method development in academic and industrial research exploring new synthetic methodologies.
• Chiral Resolution: Potential use in the development of chiral stationary phases or resolving agents for the separation of enantiomers.
• Fine Chemical Synthesis: Enabling the production of enantiomerically enriched flavors, fragrances, and agrochemical intermediates.

Basic Information

Product Name	(8α,9S)-10,11-Dihydro-9-Isocyano-6'-Methoxy-Cinchonan
CAS No.	1312706-37-8
Molecular Formula	C₂₁H₂₃N₃O₂
Molecular Weight	349.43 g/mol
Synonyms	9-Isocyano-10,11-dihydro-6'-methoxycinchonan; Dihydroquinine isocyanide; 9-Isocyano-10,11-dihydroquinine; (8α,9S)-10,11-Dihydro-9-isocyano-6'-methoxycinchonan; Cinchonan, 10,11-dihydro-9-isocyano-6'-methoxy-, (8α,9S)-; 1312706-37-8; (8alpha,9S)-10,11-Dihydro-9-isocyano-6'-methoxycinchonan
EINECS	Contact for details

Quality Control

Our (8α,9S)-10,11-Dihydro-9-Isocyano-6'-Methoxy-Cinchonan is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.