Description

2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridin-1(2H)-Yl)Pyrimidine is a high-value, advanced pharmaceutical intermediate belonging to the class of protected boronic acid esters. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction to construct complex molecular architectures. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted small-molecule therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester coupling partner for the formation of carbon-carbon bonds between aromatic and heteroaromatic systems.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize lead compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development pipelines.
• Academic Research: Utilized in universities and institutes for methodological development in organic synthesis and catalysis.

Basic Information

Product Name	2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridin-1(2H)-Yl)Pyrimidine
CAS No.	1312479-75-6
Molecular Formula	C15H22BN3O2
Molecular Weight	287.17 g/mol
Synonyms	1,3,2-Dioxaborolane, 2-[1-(2-pyrimidinyl)-1,2,3,6-tetrahydro-4-pyridinyl]-4,4,5,5-tetramethyl-; 2-[1-(Pyrimidin-2-yl)-1,2,3,6-tetrahydropyridin-4-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridin-1-yl)pyrimidine; 2-(4-(Pinacolatoboryl)-1,2,3,6-tetrahydropyridin-1-yl)pyrimidine; 1-(Pyrimidin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridin-1(2H)-Yl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.