Description

(R)-Ethyl 4-Bromo-2-Methyl-2-(Methylsulfonyl)Butanoate is a high-value chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring a bromine handle and a methylsulfonyl group, makes it a versatile precursor for constructing complex molecules with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its stereochemistry can influence biological activity.
• Asymmetric Synthesis: Serves as a critical starting material or electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) and other stereoselective transformations to introduce complex side chains.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, exploring new reaction pathways, and creating compound libraries for screening.
• Material Science Precursor: Potential use in the synthesis of specialized monomers or ligands for advanced polymeric materials and catalysts.

Basic Information

Product Name	(R)-Ethyl 4-Bromo-2-Methyl-2-(Methylsulfonyl)Butanoate
CAS No.	1312478-48-0
Molecular Formula	C8H15BrO4S
Molecular Weight	287.17 g/mol
Synonyms	Ethyl (R)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate; (R)-Ethyl 4-bromo-2-methyl-2-(methylsulphonyl)butyrate; 4-Bromo-2-methyl-2-(methylsulfonyl)butanoic acid ethyl ester, (R)-; Butanoic acid, 4-bromo-2-methyl-2-(methylsulfonyl)-, ethyl ester, (R)-; (R)-4-Bromo-2-methyl-2-(methylsulfonyl)butyric acid ethyl ester; (R)-Ethyl 4-bromo-2-methyl-2-(mesyl)butanoate; (R)-EBMMB
EINECS	Contact for details

Quality Control

Our (R)-Ethyl 4-Bromo-2-Methyl-2-(Methylsulfonyl)Butanoate is manufactured under strict quality control protocols to ensure high chemical purity and enantiomeric excess (e.e.) suitable for demanding synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% e.e.
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.