Description

2-Bromo-3-Fluoro-1-Methylpyridin-4(1H)-One is a high-value, multi-functional halogenated pyridinone building block essential for modern synthetic chemistry. This compound matters for its unique reactivity profile, offering chemists a versatile handle for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and scalable synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the bromo and fluoro substituents enhance biological activity and stability.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Nucleophilic Substitution: The activated position allows for further functionalization, enabling the introduction of diverse amines, alkoxides, and thiols.
• Library Synthesis for Drug Discovery: Employed in high-throughput and parallel synthesis to generate diverse compound libraries for screening against novel biological targets.

Basic Information

Product Name	2-Bromo-3-Fluoro-1-Methylpyridin-4(1H)-One
CAS No.	1312440-89-3
Molecular Formula	C6H5BrFNO
Molecular Weight	206.01 g/mol
Synonyms	2-Bromo-3-fluoro-1-methyl-4(1H)-pyridinone; 2-Bromo-3-fluoro-1-methylpyridin-4-one; 1-Methyl-2-bromo-3-fluoro-4-pyridone; 4(1H)-Pyridinone, 2-bromo-3-fluoro-1-methyl-; 2-Bromo-3-fluoro-1-methyl-1,4-dihydropyridin-4-one
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Fluoro-1-Methylpyridin-4(1H)-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is available for each lot, confirming identity, purity, and impurity profiles via validated methods such as HPLC, GC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.