Description

Azido-PEG2-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group and a carboxylic acid terminus. This compound is essential for creating stable, biocompatible conjugates in bioconjugation and materials science, enabling the connection of biomolecules or surfaces via click chemistry and carbodiimide coupling. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material synthesis who require reliable, high-purity building blocks for drug delivery systems, diagnostic assays, and surface functionalization.

Application

• Bioconjugation and ADC Development: Used as a linker to attach cytotoxic drugs, antibodies, or fluorescent dyes via its azide (click chemistry) and carboxylic acid (amide bond formation) functionalities.
• PEGylation and Drug Delivery: Serves as a spacer to PEGylate therapeutic peptides, proteins, or nanoparticles, enhancing solubility, stability, and circulation time.
• Surface Functionalization: Enables the modification of nanoparticles, biosensors, and microarray slides with specific ligands or biomolecules for targeted applications.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker in hydrogel formation and polymer network construction for tissue engineering and controlled release systems.
• Proteomics Research: Utilized in chemical proteomics for labeling and enriching proteins or studying protein-protein interactions.
• Diagnostic Reagent Synthesis: A key intermediate in the production of contrast agents, imaging probes, and diagnostic kits.

Basic Information

Product Name	Azido-PEG2-Acid
CAS No.	1312309-63-9
Molecular Formula	C9H17N3O5
Molecular Weight	247.25 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]acetic acid; Azido-PEG2-CH2COOH; 3,6-Dioxa-8-azaoctanoic acid, 8-azido-; Azido-EG2-acid; N3-PEG2-COOH; 8-Azido-3,6-dioxaoctanoic acid; Azido(triethylene glycol)acetic acid; PEG2-azide-acid
EINECS	Contact for details

Quality Control

Our Azido-PEG2-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and production applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.