Description

(S)-1-(3-Chloro-5-Trifluoromethyl-Pyridin-2-Yl)-Pyrrolidin-3-Ol is a high-purity chiral intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a key building block for the development of novel, biologically active molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists and manufacturers engaged in creating advanced agrochemicals and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and synthesis of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Serves as a key precursor in the development of next-generation pesticides and herbicides, leveraging its unique pyridine-pyrrolidine scaffold.
• Ligand & Catalyst Development: Used in asymmetric synthesis as a component for constructing novel chiral ligands and organocatalysts.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new chemical entities and reaction pathways in medicinal chemistry.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.

Basic Information

Product Name	(S)-1-(3-Chloro-5-Trifluoromethyl-Pyridin-2-Yl)-Pyrrolidin-3-Ol
CAS No.	1311776-29-0
Molecular Formula	C10H10ClF3N2O
Molecular Weight	266.65 g/mol
Synonyms	(S)-1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-ol; (3S)-1-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinol; (S)-1-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-pyrrolidin-3-ol; 1311776-29-0; (S)-3-Hydroxy-1-(3-chloro-5-trifluoromethyl-2-pyridyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-1-(3-Chloro-5-Trifluoromethyl-Pyridin-2-Yl)-Pyrrolidin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard spectroscopic methods for identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to fluoride/strong alkali conditions, keep away from incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.