Description

4-(3-Chloro-5-Trifluoromethyl-Pyridin-2-Ylmethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a piperazine core protected by a tert-butyloxycarbonyl (Boc) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with targeted biological activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Synthesis: Intermediate for developing novel herbicides, fungicides, or insecticides that leverage the pyridine and piperazine motifs.
• Boc-Protected Piperazine Source: Provides a protected piperazine moiety for peptide mimetics and other complex organic syntheses, where the Boc group allows for selective deprotection.
• Ligand and Catalyst Development: Potential precursor for creating specialized ligands used in catalysis or diagnostic agents.

Basic Information

Product Name	4-(3-Chloro-5-Trifluoromethyl-Pyridin-2-Ylmethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1311278-11-1
Molecular Formula	C17H21ClF3N3O2
Molecular Weight	391.82 g/mol
Synonyms	tert-Butyl 4-[[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl]piperazine-1-carboxylate; 1-Boc-4-[(3-chloro-5-trifluoromethyl-2-pyridyl)methyl]piperazine; 4-[(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl]piperazine; BOC-4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)piperazine; 1311278-11-1; 4-(3-Chloro-5-trifluoromethyl-pyridin-2-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 4-(3-Chloro-5-Trifluoromethyl-Pyridin-2-Ylmethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.