Description

Ethyl 4-(Difluoromethoxy)-3-Hydroxybenzoate is a high-value fluorinated aromatic ester building block with significant utility in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoromethoxy and phenolic hydroxyl groups offer unique reactivity and influence on molecular properties. Pharmaceutical R&D teams and fine chemical manufacturers need it for constructing complex molecules, particularly in medicinal chemistry programs targeting new therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluoromethoxy group can enhance bioavailability and stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated monomers used in the production of advanced display technologies.
• Polymer Modification: Incorporated into specialty polymers to impart specific chemical resistance or altered surface properties.
• Organic Synthesis Research: Employed in academic and industrial labs for method development and exploring new fluorination chemistry pathways.
• Complex Ligand Preparation: Used to synthesize specialized ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	Ethyl 4-(Difluoromethoxy)-3-Hydroxybenzoate
CAS No.	1311198-39-6
Molecular Formula	C10H10F2O4
Molecular Weight	232.18 g/mol
Synonyms	Ethyl 3-Hydroxy-4-(difluoromethoxy)benzoate; Benzoic acid, 4-(difluoromethoxy)-3-hydroxy-, ethyl ester; 4-(Difluoromethoxy)-3-hydroxybenzoic Acid Ethyl Ester; 3-Hydroxy-4-(difluoromethoxy)benzoic Acid Ethyl Ester; Ethyl 4-(Difluoromethoxy)-3-hydroxybenzoate; DFMB Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-(Difluoromethoxy)-3-Hydroxybenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements of our pharmaceutical and R&D clients. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.