Description

tert-Butyl 3-Hydroxycyclobutanecarboxylate is a high-purity chemical building block featuring a cyclobutane ring substituted with both a hydroxyl group and a tert-butyl ester. This compound matters as a versatile chiral intermediate, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily needed by pharmaceutical and advanced agrochemical R&D teams for constructing novel active ingredients and by fine chemical manufacturers producing specialized intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in creating advanced, stereochemically-defined active ingredients for next-generation herbicides and fungicides.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with tailored properties.
• Academic & Industrial R&D: A valuable tool for synthetic organic chemists exploring new reaction methodologies and complex molecular architectures.

Basic Information

Product Name	tert-Butyl 3-Hydroxycyclobutanecarboxylate
CAS No.	1311166-10-5
Molecular Formula	C9H16O3
Molecular Weight	172.22 g/mol
Synonyms	3-Hydroxycyclobutanecarboxylic acid tert-butyl ester; tert-Butyl 3-hydroxycyclobutanecarboxylate; 1,1-Dimethylethyl 3-hydroxycyclobutanecarboxylate; 3-(tert-Butoxycarbonyl)cyclobutanol; Cyclobutanecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Hydroxycyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.