Description

trans-tert-Butyl 3-Hydroxycyclobutanecarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclobutane ring structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals, offering a versatile chiral building block for medicinal chemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new therapeutic agents and high-value products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel APIs, particularly for central nervous system (CNS) and antiviral drugs.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced herbicides and pesticides with specific stereochemical requirements.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced materials with tailored properties.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial production of fine chemicals.

Basic Information

Product Name	trans-tert-Butyl 3-Hydroxycyclobutanecarboxylate
CAS No.	1311158-43-6
Molecular Formula	C9H16O3
Molecular Weight	172.22 g/mol
Synonyms	tert-Butyl (1r,3r)-3-Hydroxycyclobutanecarboxylate; (1r,3r)-3-Hydroxycyclobutanecarboxylic Acid tert-Butyl Ester; trans-3-Hydroxycyclobutanecarboxylic Acid tert-Butyl Ester; (R,R)-tert-Butyl 3-Hydroxycyclobutanecarboxylate; 3-Hydroxycyclobutanecarboxylic Acid 1,1-Dimethylethyl Ester, trans-; BOC-3-Hydroxycyclobutane-carboxylate (trans-); 1311158-43-6; tert-Butyl trans-3-Hydroxycyclobutanecarboxylate
EINECS	Contact for details

Quality Control

Our trans-tert-Butyl 3-Hydroxycyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and isomeric purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee consistent quality and traceability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isomeric Purity (Chiral HPLC)	≥ 99.0% (trans-)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.